DOI: https://njcpt.com.ng/101.1.2.33
Abstract
Background and objective: Creams are semisolid formulations for external skin and mucous membrane application. The study aimed to formulate cream from the leaves extract of Lavandula angustifolia and Aloe vera gel.
Method: Three batches (L1, L2 and L3) of the herbal cream were formulated by mixing the aqueous and oily ingredients at 75oC with a homogenizer. The formulated creams' different parameters were evaluated, such as viscosity, spreadability, pH, appearance, homogeneity, irritancy, erythema, oedema, stability and antioxidant effect.
Results: The formulated creams possessed a significant antioxidant effect with IC50 values of 2.30-6.12 mg/mL, saponification values of 20.9-28.4, acid values of 5.2-5.9, pH values of 5.5-6.2 and viscosity of 24,427-25,614 cps. The formulations also showed good washability, spreadability, consistency, texture, homogeneity, appearance, and stability, and there was no evidence of phase separation.
Conclusion: The formulated creams showed no erythema, inflammation, oedema and irritation during irritancy studies. The creams were stable at room temperature and safe for application to the skin.
Keywords: Aloe vera, cream, emulsion, Lavandula angustifolia